A New Element within the T-Cell Receptor α Locus Required for Tissue-Specific Locus Control Region Activity
نویسندگان
چکیده
منابع مشابه
Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus.
Locus control regions (LCRs) refer to cis-acting elements composed of several DNase I hypersensitive sites, which synergize to protect transgenes from integration-site dependent effects in a tissue-specific manner. LCRs have been identified in many immunologically important gene loci, including one between the TCRdelta/TCRalpha gene segments and the ubiquitously expressed Dad1 gene. Expression ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1999
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.19.3.1901